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The Juvenile Inflammatory Rheumatism cohort

“mission"

What is JIR Cohort

Learn more of JIR Cohorte

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Tutorials

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Access videos and practical resources

How to participate to the JIR Cohort

Reach our team or access the platform

Publications

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Discover research based on JIR data

Create a project

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Learn how to submit a research proposal

Regulatory framework

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Understand our regulatory framework

Ongoing projects

Access our transparency commitments

JIR cohort

The JIR Cohort is a secure, international health data warehouse dedicated to research on rare juvenile inflammatory rheumatic diseases.
It provides a structured regulatory framework, harmonized tools, and a transparent scientific governance to foster high-quality collaborative research.

Key figures (“By the numbers”):

  • +60 participating centers

  • 25 countries

  • >12,000 patients

  • 100+ research projects

  • 30+ publications

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The JIR cohort is actually active in the following 11 countries​

Network's organization

The JIRcohort is a project from the Fondation Rhumatismes-Enfants-Suisse, a Swiss non-profit foundation.

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The network is managed by a steering committee responsible for the global strategy and the finances and by a scientific committee responsible for the use of the data.

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Publications

Indications, efficacy and safety of rituximab in childhood-onset systemic lupus erythematosus: a retrospective study of the JIR cohort

Rheumatology

April 2025

Cognard J, Belot A, and al.

Lupus
Read

Iron Deficiency in Familial Mediterranean Fever: A Study
on 211 Adult Patients From the JIR Cohort

American Journal of Hematology

Nov 2024

Di Cola I., Georgin-Lavialle S., and al.

Read

Characteristics of familial Mediterranean fever after 65 years of age

European Journal of Internal Medicine

Oct 2024

Rodrigues F., Georgin-Lavialle S., and al.

FMF
Read

Ongoing projects

Note : Patients in our database who prefer not to participate in specific projects are encouraged to communicate their choice to their physicians (please mention the project name). We respect and support your decisions regarding project involvement. Thank you for being part of our valuable medical research community."

Kawasaki Anakinra - Anakinra in Kawasaki Disease: Impact on Coronary Aneurysms and Inflammatory Markers

This study evaluates the effect of Anakinra on inflammation and coronary aneurysms in children
with Kawasaki disease. It aims to improve therapeutic strategies and long-term cardiovascular
outcomes.

Perrine Dusser-Benesty, AP-HP - Bicêtre Hospital, Paris, France

CAPS-MEO : Eosinophilic meningitis associated with Cryopyrin-associated periodic syndromes

Cryopyrin-associated periodic syndromes (CAPS) are auto-inflammatory diseases caused by a mutation in the NLRP3 gene, leading to excessive inflammation. The aim of this research project is to describe the possible association between CAPS and eosinophilic meningitis, a previously undescribed complication of this disease. Eosinophilic meningitis is generally associated with infectious or inflammatory causes, and remains little studied in the context of autoinflammatory diseases.

Moscovici Cécilia, Dr Paul Legendre, CH Le Mans, France

أجسام مضادة لـ IFN-alpha2 في مجموعة فرنسية متعددة المراكز من الأطفال المصابين بمرض الذئبة الحمامية الجهازية

تقييم وجود أجسام مضادة لـ IFN-alpha2 في مجموعة فرنسية متعددة المراكز من الأطفال المصابين بمرض الذئبة الحمامية الجهازية

Alexandre Belot, دور العجزة المدنيين في ليون، ليون، فرنسا

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