PFAPA

PFAPA : Periodic fever with aphthous stomatitis, pharyngitis and adenitis (PFAPA) is the most common periodic fever syndrome of childhood. In contrast to the monogenic periodic fever syndromes, the genetic defect(s) in PFAPA have not yet been identified.

SURF : In the last few years, a subgroup of patients has been identified presenting with the typical features of recurrent inflammatory fevers, but they present no pathological variants in the genes associated with hereditary recurrent fevers (such as MEFV, MVK, TNRSF1A, NLRP3) and do not fulfil any of the current PFAPA clinical criteria.

 
 
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