JIR ongoing projects
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Juvenile Idiopathic Arthritis (JIA) in Infants
Understanding a Rare Condition in Early Childhood
Juvenile idiopathic arthritis (JIA) is a type of joint inflammation that affects children. When it appears in infants under 1 year old, it is very rare and can be difficult to recognize. Early signs might be subtle, and diagnosis can take time.
What Is This Study About?
Our study focuses on understanding how JIA shows up in babies, including:
· What the first symptoms are
· How long it takes to get a diagnosis
· What types of JIA occur
· What treatments are used
· How the condition affects children over time
We also compare these babies with slightly older children (ages 1 to 6) who also have JIA, to see how the disease might differ by age.
Takeaway Message
If your baby shows unexplained swelling, stiffness, or pain in their joints – especially without signs of infection – talk to a pediatrician or specialist. The sooner we understand what’s going on, the better we can help.
Timmy Strauss and Catharina Schuetz
Department of Pediatrics, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany
Serum calprotectin: a marker of inflammatory activity in familial Mediterranean fever
Familial Mediterranean fever (FMF) is a genetic disease characterized by recurrent episodes of inflammation. It typically requires two pathogenic variants for manifestation, but some patients with only one variant may develop moderate symptoms. Currently, no specific activity marker has been identified, as classical inflammatory markers lack specificity. This study aims to determine whether serum calprotectin could serve as a specific biomarker of FMF activity and whether it could help guide the decision to initiate colchicine treatment in heterozygous patients.
Fanny Faron, Veronique Hentgen :
Paediatric Rheumatology, Versailles Hospital, Versailles, France;
CEREMAIA: French National Reference Center for Auto-inflammatory Diseases and AA Amyloidosis, Paris, France.
Anti-IFN-alpha2 AAbs in a french multicentric cohort of pediatric patients with SLE
Assess the presence of anti-IFN-alpha2 AAbs in a french multicentric cohort of pediatric patients with SLE
Alexandre Belot, Hospices Civils de Lyon, Lyon, France
CAPS-MEO : Eosinophilic meningitis associated with Cryopyrin-associated periodic syndromes
Cryopyrin-associated periodic syndromes (CAPS) are auto-inflammatory diseases caused by a mutation in the NLRP3 gene, leading to excessive inflammation. The aim of this research project is to describe the possible association between CAPS and eosinophilic meningitis, a previously undescribed complication of this disease. Eosinophilic meningitis is generally associated with infectious or inflammatory causes, and remains little studied in the context of autoinflammatory diseases.
Dr Paul Legendre, CH Le Mans, France
Kawasaki Anakinra - Anakinra in Kawasaki Disease: Impact on Coronary Aneurysms and Inflammatory Markers
This study evaluates the effect of Anakinra on inflammation and coronary aneurysms in children
with Kawasaki disease. It aims to improve therapeutic strategies and long-term cardiovascular
outcomes.
Perrine Dusser-Benesty, AP-HP - Bicêtre Hospital, Paris, France
