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Systemic Juvenile Idiopathic Arthritis and Adult-onset Still’s disease

One same disease, diverse phenotypes, multiple challenges.

By Charlotte Girard (Switzerland)- Project CliPS - Working Group "Systemic Juvenile Idiopathic Arthritis (sJIA) and adult onset still disease (AOSD)"

Systemic Juvenile Arthritis (sJIA) and Adult-onset Still’s Disease (AOSD) are more and more recognized as a continuum of one same disease. Nonetheless, it is now common knowledge that its clinical presentation is heterogeneous, presumably reflecting diverse pathophysiology. Tremendous efforts have been, are being, and still remain to be done in order to more precisely characterize the various phenotypes of sJIA and AOSD. Better comprehension of the disease will indeed allow more appropriate therapeutic strategies and follow-up, including screening of life-threatening complications, among which macrophage activation syndrome (MAS). The JIR-CliPS sJIA/AOSD working group is in line with this approach.

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